Hinrunde
| 19.09.2021 | SV DJK Holzbüttgen | (A) | : |
| 26.09.2021 | TV Refrath | (A) | : |
| 02.10.2021 | TSSV Bottrop | (A) | : |
| 10.10.2021 | Schwalbe Bergneustadt II | (H) | : |
| 16.10.2021 | TTG St. Augustin | (A) | : |
| 30.10.2021 | SC Arminia Ochtrup | (A) | : |
| 07.11.2021 | SC Bayer 05 Uerdingen | (H) |
: |
| 14.11.2021 | GSV Fröndenberg | (H) | : |
| 20.11.2021 |
TTC Waldniel | (A) |
: |
| 28.11.2021 | TB Burgsteinfurt | (H) | : |
| 04.12.2021 | TTC Champions Düsseldorf | (A) | : |
| 12.12.2021 |
Borussia Düsseldorf II | (H) |
: |
Rückrunde
| 16.01.2022 | TTC Waldniel | (H) | : |
| 30.01.2022 | SV DJK Holzbüttgen | (H) | : |
| 06.02.2022 | TV Refrath | (H) | : |
| 13.02.2022 | TSSV Bottrop | (H) | : |
| 19.02.2022 | Schwalbe Bergneustadt II | (A) | : |
| 06.03.2022 | SC Arminia Ochtrup | (H) | : |
| 12.03.2022 | SC Bayer 05 Uerdingen | (A) |
: |
| 19.03.2022 | GSV Fröndenberg | (A) | : |
| 02.04.2022 |
TB Burgsteinfurt | (A) |
: |
| 10.04.2022 | TTC Champions Düsseldorf | (H) | : |
| 23.04.2022 | Borussia Düsseldorf II | (A) | : |
| 30.04.2022 |
TTG St. Augustin | (H) |
: |
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