Hinrunde
| 04.09.2021 | 1.FC Köln IV | (H) | 4:9 |
| 18.09.2021 | SuS Borussia Brand | (A) | : |
| 25.09.2021 | TTC BW Grevenbroich II | (H) | : |
| 02.10.2021 | TTG Langenfeld | (A) | : |
| 09.10.2021 | TTC Mödrath | (H) | : |
| 30.10.2021 | TuS Porselen | (A) |
: |
| 06.11.2021 | SSV Germania Wuppertal | (H) | : |
| 13.11.2021 |
SV DJK Holzbüttgen II | (H) |
: |
| 20.11.2021 | TTC BW Lechenich | (A) | : |
| 27.11.2021 | TTC Union Düsseldorf | (H) | : |
| 04.12.2021 | TSV Krefeld-Bockum | (A) |
: |
Rückrunde
| 15.01.2022 | 1.FC Köln IV | (A) | : |
| 29.01.2022 | SuS Borussia Brand | (H) | : |
| 05.02.2022 | TTC BW Grevenbroich II | (A) | : |
| 12.02.2022 | TTG Langenfeld | (H) | : |
| 19.02.2022 | TTC Mödrath | (A) | : |
| 05.03.2022 | TuS Porselen | (H) |
: |
| 12.03.2022 | SSV Germania Wuppertal | (A) | : |
| 19.03.2022 |
SV DJK Holzbüttgen II | (A) |
: |
| 26.03.2022 | TTC BW Lechenich | (H) | : |
| 03.04.2022 | TTC Union Düsseldorf | (A) | : |
| 09.04.2022 | TSV Krefeld-Bockum | (H) |
: |